Loss of methionine sulfoxide reductases increases resistance to oxidative stress

Role of methionine sulfoxide reductases A and B of Enterococcus faecalis in oxidative stress and virulence.

Methionine sulfoxide reductases A and B are antioxidant repair enzymes that reduce the S- and R-diastereomers of methionine sulfoxides back to methionine, respectively. Enterococcus faecalis, an important nosocomial pathogen, has one msrA gene and one msrB gene situated in different parts of the chromosome. Promoters have been mapped and mutants have been constructed in two E. faecalis strains ...

Protection of Mouse Embryonic Stem Cells from Oxidative Stress by Methionine Sulfoxide Reductases

Methionine sulfoxide reductases protect against oxidative stress in Staphylococcus aureus encountering exogenous oxidants and human neutrophils.

To establish infection successfully, Staphylococcus aureus must evade clearance by polymorphonuclear neutrophils (PMN). We studied the expression and regulation of the methionine sulfoxide reductases (Msr) that are involved in the repair of oxidized staphylococcal proteins and investigated their influence on the fate of S. aureus exposed to oxidants or PMN. We evaluated a mutant deficient in ms...

Methionine sulfoxide reductase A is important for lens cell viability and resistance to oxidative stress.

Age-related cataract, an opacity of the eye lens, is the leading cause of visual impairment in the elderly, the etiology of which is related to oxidative stress damage. Oxidation of methionine to methionine sulfoxide is a major oxidative stress product that reaches levels as high as 60% in cataract while being essentially absent from clear lenses. Methionine oxidation results in loss of protein...

Methionine-r-sulfoxide Reductases and Biological Importance of Free Methionine Sulfoxide Reduction